Dr. Mario (Dr. マリオ, Dokutā Mario) is a doctor-costumed version of Mario that is the star of his eponymous game for the Nintendo Entertainment System, Game Boy, and Super Nintendo Entertainment System. He also stars in Dr. Mario 64 for the Nintendo 64, Dr. Mario and Puzzle League for the Game Boy Advance, and in Dr. Mario Online Rx, which is a game for Wii's WiiWare. In Super Smash Bros. Melee, he is an unlockable character.
 Character description
Dr. Mario is simply Mario in a doctor's uniform, equipped with his powerful "Megavitamins" to fight against viruses (Blue, Red and Yellow Viruses). He originated in the 1990 NES/Game Boy game Dr. Mario.
 In Super Smash Bros.
In the original game, Dr. Mario was briefly mentioned in Mario's biography, among his many other past professions.
 In Super Smash Bros. Melee
 As a Playable Character
Dr. Mario appears in Super Smash Bros. Melee as one of the thirteen new characters introduced. He is a secret character and considered to be a "clone" of Mario's. Dr. Mario is a stronger version of Mario that is supposed to be slower (though in actuality, his speed attributes are either equal to or actually greater than Mario's). While not many significant differences exist between the two characters, there are a few; the main one being that rather than shooting Fireballs as his neutral special move, he throws Megavitamins. The subtle differences between Dr. Mario and Mario, in the competitive scene, work to Dr. Mario's favor (mainly his much superior KO power), and place him five places higher on the current tier list.
Dr. Mario, like the rest of the playable characters, has three different trophies dedicated to him. The Viruses from the Dr. Mario game also appear as a trophy. His Classic mode trophy is as follows:
Dr. Mario Immaculate in his medical garb, Dr. Mario destroys killer viruses with his amazing vitamin capsules. With his dedicated nurse, Princess Peach, at his side, Dr. Mario spends day and night in his laboratory working on new miracle cures. Somehow he's managed to keep up with all the new viruses that have arisen over the years.
Dr. Mario was one of the five playable characters who didn't return in Brawl. However, he still has some representation in the game through the following:
Dr. Mario receives representation in Brawl with two music tracks: